Targeting Interleukin-6 Signaling in Clinic
نویسندگان
چکیده
منابع مشابه
SorLA in Interleukin-6 Signaling and Turnover
Interleukin-6 (IL-6) is a multifunctional cytokine with important functions in various physiologic processes. Mice lacking IL-6 exhibit multiple phenotypic abnormalities, such as an inadequate immune and acute-phase response, and elevated levels of circulating IL-6 have been found to accompany several pathological conditions. IL-6 binds the nonsignaling IL-6 receptor (IL-6R), which is expressed...
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Diabetic kidney disease is characterized by increased albuminuria associated with structural changes, such as thickening of the glomerular basement membrane, mesangial expansion, and podocyte depletion followed by glomerulosclerosis. Glomerulosclerosis is preceded by early hypertrophic changes in the glomerulus [1]. Among the many characteristic glomerular pathologic changes, a decrease in the ...
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127 Received August 25, 2014; revised and accepted January 28, 2015. Published online February 20, 2015; doi: 10.1620/tjem.235.127. Correspondence: Takeshi Sato, M.D., Department of Gastroenterology, Yamagata University Faculty of Medicine, 2-2-2 Iida-Nishi, Yamagata, Yamagata 990-9585, Japan. e-mail: [email protected] Treatment with Anti-Interleukin-6 Receptor Antibody Ameliorat...
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Interleukin-6 (IL-6) is a pleiotropic cytokine implicated in the pathogenesis of many immune-mediated disorders including several types of non-infectious uveitis. These uveitic conditions include Vogt-Koyanagi-Harada syndrome, uveitis associated with Behçet disease, and sarcoidosis. This review summarizes the role of IL-6 in immunity, highlighting its effect on Th17, Th1, and plasmablast differ...
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Three forms of interleukin-6 (IL-6) have been constructed and stably transfected into human hepatoma cells (HepG2). Wild type IL-6 containing a signal peptide was rapidly secreted as a biologically active protein. IL-6 lacking the signal peptide accumulated within the cytoplasm of transfected cells. Surprisingly, IL-6 carrying a COOH-terminal extension of the amino acids Lys-Asp-Glu-Leu (KDEL) ...
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ژورنال
عنوان ژورنال: Immunity
سال: 2019
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2019.03.026